منابع مشابه
Memory T Cell Migration
Immunological memory is a key feature of adaptive immunity. It provides the organism with long-lived and robust protection against infection. In organ transplantation, memory T cells pose a significant threat by causing allograft rejection that is generally resistant to immunosuppressive therapy. Therefore, a more thorough understanding of memory T cell biology is needed to improve the survival...
متن کاملT cell metabolism drives immunity
Lymphocytes must adapt to a wide array of environmental stressors as part of their normal development, during which they undergo a dramatic metabolic remodeling process. Research in this area has yielded surprising findings on the roles of diverse metabolic pathways and metabolites, which have been found to regulate lymphocyte signaling and influence differentiation, function and fate. In this ...
متن کاملT-Cell Metabolism in Hematopoietic Cell Transplantation
Metabolism, including catabolism and anabolism, is a basic cellular process necessary for cell survival. T lymphocytes have a distinct metabolism that can determine both fate and function. T-cell activation depends on glycolysis to obtain materials and energy for proliferation and effector function. Importantly, T cells utilize different metabolic processes under different conditions and diseas...
متن کاملEnergy Metabolism and T-cell-mediated Cytolysis
The destruction of appropriate target cells by cytolytic thymus-derived lymphocytes (CTL) 1 is an active energy-requiring phenomenon (1-3). In the accompanying paper (4), we presented evidence that T-cell-mediated cytolysis could be supported by either oxidative or glycolytic energy pathways and was in general strongly inhibited only in those situations in which both respiration and glycolysis ...
متن کاملInhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function.
Naive CD8+ T cells rely upon oxidation of fatty acids as a primary source of energy. After antigen encounter, T cells shift to a glycolytic metabolism to sustain effector function. It is unclear, however, whether changes in glucose metabolism ultimately influence the ability of activated T cells to become long-lived memory cells. We used a fluorescent glucose analog, 2-NBDG, to quantify glucose...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Blood
سال: 2018
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2018-99-109535